Reduced All-Cause Mortality in the ETHOS Trial of Budesonide/Glycopyrrolate/Formoterol for Chronic Obstructive Pulmonary Disease. A Randomized, Double-Blind, Multicenter, Parallel-Group Study
نویسندگان
چکیده
Rationale: In the phase III, 52-week ETHOS (Efficacy and Safety of Triple Therapy in Obstructive Lung Disease) trial chronic obstructive pulmonary disease (COPD) (NCT02465567), triple therapy wi...
منابع مشابه
Dexamethasone vs Hydrocortisone in Management of Exacerbated Chronic Obstructive Pulmonary Disease Patients: A Randomized Controlled Trial
Background: Different types of corticosteroids with different characteristics, such as hydrocortisone and dexamethasone, have been used in treatment of exacerbated chronic obstructive pulmonary disease but drug of choice unclear. The main goal of present study was to compare the efficacy of hydrocortisone and dexamethasone on clinical symptoms, peak expiratory flow, oxidative stress factors and...
متن کاملMucolytic Effectiveness of Tyloxapol in Chronic Obstructive Pulmonary Disease - A Double-Blind, Randomized Controlled Trial
OBJECTIVE Mucoactive drugs should increase the ability to expectorate sputum and, ideally, have anti-inflammatory properties. The aim of the study was to evaluate the mucolytic activity of Tyloxapol compared to saline (0.9%) in COPD. DESIGN A randomized, placebo-controlled, double-blinded crossover, clinical trial was carried out. Patients were randomly assigned to either inhale 5 ml Tyloxapo...
متن کاملGhrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
BACKGROUND Pulmonary cachexia is common in advanced chronic obstructive pulmonary disease (COPD), culminating in exercise intolerance and a poor prognosis. Ghrelin is a novel growth hormone (GH)-releasing peptide with GH-independent effects. The efficacy and safety of adding ghrelin to pulmonary rehabilitation (PR) in cachectic COPD patients were investigated. METHODOLOGY/PRINCIPAL FINDINGS I...
متن کاملComparison of the quality of life in patients with chronic obstructive pulmonary disease and control group
Introduction: Chronic obstructive pulmonary disease (COPD) is the fourth cause of mortality and a leading cause of chronic disability worldwide. Given the nature of the disease and lack of any effective treatment, it can profoundly affect the quality of life (QOL) of patients. Studies about the effect of COPD on QOL have yielded contradictory results however, most studies suggest that COPD ne...
متن کاملHealth promotion nursing activities for the elderly with chronic obstructive pulmonary disease: A cross-sectional study
Background & Aim: Health promotion nursing activities for the elderly with COPD is different in various health care structures, and research in this area can help to identify the existing knowledge gap. The aim of this study was to determine health promotion nursing activities for the elderly with COPD. Methods & Materials: This descriptive, cross-sectional study was conducted in 2020. A total...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2021
ISSN: ['1073-449X', '1535-4970']
DOI: https://doi.org/10.1164/rccm.202006-2618oc